Dr. Charles Brenner on the Surprising Science of Aging

October 11, 2018
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Dr. Charles Brenner, the Roy J. Carver Chair of Biochemistry at the University of Iowa and Chief Scientific Advisor at ChromaDex, the makers of TRU NIAGEN joins eHealth Radio & the Health News Channel to discuss surprising science behind aging.

 

Listen to interview with host Eric Michaels and guest Dr. Charles Brenner discuss the following:

  1. What is NAD? What has your research revealed about it?
  2. What is the relationship between NAD and aging?
  3. What is NIAGEN, and how is it related to NAD?
  4. Does increasing NAD levels have any other benefits, besides anti-aging? Are these potential benefits being studied in clinical studies?  

 

Dr. Charles Brenner Dr. Charles Brenner is the Roy J. Carver Chair and Head of Biochemistry at the University of Iowa, as well as a founding co-director of the University of Iowa Obesity Initiative. In 2004, Brenner, then a faculty member at Dartmouth College, discovered nicotinamide riboside (NR) to be a vital precursor of nicotinamide adenine dinucleotide (NAD+), which is made available by nicotinamide riboside kinases (Nrks) that are conserved between yeast and humans. In 2007, Dr. Brenner's lab discovered a second pathway by which NR is converted to NAD+ and showed that NR can extend the lifespan of yeast cells by virtue of elevating NAD+ levels and increasing the activity of the NAD+ dependent Sir2 enzyme.

In the past decade, Dr. Brenner has made multiple seminal contributions to NAD+ metabolism, which include engineering a yeast strain to convert inexpensive NAD+ precursor vitamins into NR, solving the crystal structure of human Nrk1, developing the methods for quantitative NAD+ metabolomics, and demonstrating the activity of oral NR in animal models of fatty liver disease, obesity, type 2 diabetes, diabetic and chemotherapeutic neuropathy, heart failure, and central brain injury. Dr. Brenner also led the first clinical trial of NR, which established safe oral availability in humans. He is currently focusing on the maternal and neonatal effects of oral NR and translating animal discoveries into evidence-based safe, human clinical practice for human conditions of metabolic stress.

 

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Website: www.truniagen.com | www.aboutNAD.com

Social Media Links:
Facebook: https://www.facebook.com/TruNiagen
Twitter: https://twitter.com/truniagen

Medical device company focused on developing restoration treatments for patients with spinal cord-injuries

October 5, 2018
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Dr. Richard Toselli, CEO of the InVivo Therapeutics Corporation a research and clinical-stage biomaterials and biotechnology company with a focus on treatment of spinal cord injuries joins eHealth Radio and the Health News & Spinal Health Channels.

 

Listen to interview with host Eric Michaels and guest Dr. Richard Toselli discuss the following:

  1. Can you tell our audience about InVivo Therapeutics and what your company does?
  2. You have an interesting background for a CEO, not a typical one. You’re a former neuro surgeon. Can you tell our audience which has an interest in healthcare and business a bit about your background and how it translates to your current role as CEO of InVivo Therapeutics?
  3. What’s more difficult and challenging being a neuro-surgeon or the ceo of a publicly traded company haha?
  4. You became CEO earlier this year, and reading some news on you and the company it was reported that you have made some major changes with the company under your leadership such as decreasing the cash burn rate, launching a second spinal trial. Can you discuss that and also discuss the second trial as well.
  5. Can you talk a bit about product development with your company and how the process works so our listeners can understand.
  6. The spinal chord industry is constantly evolving and changing. Can you chat a bit about the industry and where it’s going and where your company fits within this industry.
  7. We know wall street is not always patient. How do companies like yours juggle the interests of investors with what you do with research and development and clinical trials etc.
  8. Where do you see this company going in the next 3 to 5 years, what do you hope to accomplish.

 

Prior to joining InVivo, Dr. Toselli served as Chief Medical Officer for Cochlear Limited. In that role, he was responsible for global clinical, regulatory, and medical affairs teams reporting to the CEO. Prior to that, Dr. Toselli served five years at Sanofi in various levels of increasing responsibility, including Vice President of Global Medical Affairs – Immunology and Inflammation, Biologics Division; Vice President of Global Medical Affairs and Head of the Biosurgery Discovery Performance Unit; and Vice President of Global Medical Affairs, Biosurgery.

Before his time at Sanofi, he served as Chief Medical/Technology Officer for Covidien Surgical, and earlier held various roles at DePuy Spine including Director of Medical Affairs, Worldwide Vice President of Research and Development, and Worldwide Vice President of Clinical Evidence and External Relations. He subsequently held the position of Vice President of Evidence-Based Medicine at Johnson & Johnson for the device sector.

Dr. Toselli’s previous academic positions include Assistant Professor at Brown University, Associate Professor, Director of Spine Center, and Associate Chief of Staff at the University of North Carolina (UNC), and Associate Professor at the University of Vermont. He holds a bachelor of arts from Providence College, his medical degree from Brown University, and a masters of business administration from the UNC’s Kenan-Flagler Business School. Dr. Toselli is a board-certified neurological surgeon.

InVivo Therapeutics Holdings Corporation is a research and clinical-stage biomaterials and biotechnology company with a focus on treatment of spinal cord injuries. The company was founded in 2005 with proprietary technology co-invented by Robert Langer, Sc.D., Professor at Massachusetts Institute of Technology, and Joseph P. Vacanti, M.D., who then was at Boston Children’s Hospital and who now is affiliated with Massachusetts General Hospital. In January 2018, the company announced updated clinical evidence, including improvements in patients with acute spinal cord injury (SCI), from its INSPIRE study of the Neuro-Spinal Scaffold™. The publicly traded company is headquartered in Cambridge, MA.

 

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Website: www.invivotherapeutics.com

#Trichotillomania: What it is & how you can take control with HabitAware CoFounder, Aneela Idnani

October 4, 2018
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Aneela Idnani, Co-Founder & "Chief Trichster" at HabitAware joins eHealth Radio and the Health News & Technology Channels. She is the inspiration for HabitAware's Keen smart bracelet to help people overcome unwanted behaviors like compulsive hair pulling, skin picking and nail biting.

 

Listen to interview with host Eric Michaels and guest Aneela Idnani discuss the following:

  1. Tell us a little bit about your experience with compulsive hair pulling disorder, also known as trichotillomania?
  2. How did you come up with the idea to use technology to help you & how does the Keen bracelet work?
  3. What resources are out there for someone who may just be realizing they have Body Focused Repetitive Behaviors?
  4. What does recovery mean to you personally?
  5. Can you please share one thing someone can do today to get started on their journey to BFRB awareness and recovery?

 

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Aneela Idnani is Cofounder & President/CMO of HabitAware. HabitAware uses patented wearable technology to help people “Retrain The Brain” from detrimental behaviors to positive ones and on becoming the standard of care for debilitating mental health conditions.

Aneela is also an outspoken mental health advocate, having grown up with a common, yet relatively unknown condition called #trichotillomania (compulsive hair pulling). Aneela is a HAX hardware accelerator alumnus and her company recently received a research grant from the NIH to improve their device and validate Keen as a treatment for trichotillomania and sister disorders. Her life’s work (HabitAware) has been featured on TechCrunch, The Washington Post, Prevention Magazine and more.

 

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Website: www.habitaware.com

Social Media Links:
Facebook: www.facebook.com/habitaware
Twitter: www.twitter.com/habitaware
Instagram: www.instagram.com/habitaware

Movement and Your Musculoskeletal Health

October 3, 2018
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Dr. Robert Hayden, DC, PhD, a Chiropractor from Griffin, Georgia, who is also a delegate of the American Chiropractic Association joins eHealth Radio and the Chiropractic & Health News Channels. ACA represents members of the chiropractic profession nationwide and advocates for issues that are important to chiropractors and their patients.

 

Listen to interview with host Eric Michaels and guest Dr. Robert Hayden discuss the following:

  1. We hear a lot about how physical activity can benefit our cardiovascular system, help us lose weight and get fit. But how does movement help our bones, muscles and joints—also known as the musculoskeletal system?
  2. Why does moving get harder as we age? Can we prevent or slow down the aging process on our bones, muscles and joints?
  3. In your experience, what are the top reasons why people aren’t moving more?
  4. For years we were told to restrict physical activity when we had back pain. Why was that bad advice? How does movement help people heal?
  5. How can people get moving? What are some of the best activities for those who may be largely inactive right now?

 

Dr. Robert Hayden maintains a private practice in Griffin, Georgia, just south of Atlanta. Dr. Hayden is a past president of the Georgia Chiropractic Association and was named the organization’s "Chiropractor of the Year" in 2006.

Prior to receiving his doctor of chiropractic degree, Dr. Hayden was a cardiovascular clinical nurse specialist. He devoted 18 years to the nursing profession, serving as executive director of the Mississippi Nurses’ Association, and as a registered lobbyist and continuing education consultant.

Dr. Hayden holds bachelor’s degrees in chemistry and nursing, and received his master’s degree in nursing from the University of Alabama. He also holds a PhD from the University of Mississippi and in 1995 received his doctor of chiropractic degree from Life University.

 

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Website: www.acatoday.org

Social Media Links:
Facebook: www.facebook.com/acatoday.org
Twitter: www.twitter.com/acatodaday